Season 1
Pilot
Dr. Michaela Quinn (Jane Seymour) from Boston answers an ad requiring a Doctor in Colorado Springs, Colorado Territory. This is after her father dies, who was her partner and mentor. It is post civil war and no one wants to accept a lady doctor. She meets Charlotte Cooper (Diane Ladd),a mid-wife and her three children. Everyone gives her a hard time, except mountain man Byron "Sully" (Joe Lando) who is a widower. She soon inherits Charlotte's children, after Charlotte suffers a fatal snake bite. Dr. Quinn is single and inexperienced where children are concerned and does her best to make the children feel at home. The youngest boy Brian runs away. She goes to search for him and is taken to an indian camp, where she finds Sully. She meets Cheyenne Chief Black Kettle (Nick Ramus) who agrees to send some of his men to help search for the boy. They find Brian, despite the army trying to bring harm to the indians who befriended her. After Chief Black Kettle and his people are attacked by the army at Sandcreek, she pulls a bullet out of his neck. Chief Black Kettle gives her her Cheyenne name "Medicine Woman".
Epidemic
An influenza epidemic sweeps through town. People are dying and Dr. "Mike" as she is affectionately called, doesn't have a clinic to treat her patients. The foreclosed boarding house which was run by Charlotte, is made into a temporary clinic. Michaela falls ill with the disease and it is left up to Sully to see that she survives.